Spectra 10 vaccine1/14/2024 ![]() In a likely reflection of this, devastating numbers of malaria deaths have been reported in 2020, 4 and the first malaria vaccine, despite its modest efficacy, was approved by the World Health Organization in 2021. 1, 3 Additionally, the global spread of the COVID-19 pandemic in early 2020 jammed the healthcare system, putting a soft halt in the fight against malaria. These efforts, however, were hampered by the growing parasites’ resistance strains to common anti-malarial drugs in endemic, under-resourced regions. Nevertheless, the past two decades have witnessed unprecedented success in reducing the mortality rate. Low-density malaria parasitemia in asymptomatic individuals at the early stage of infection goes undiagnosed or unnoticed, which serves as a reservoir for future infections and hinders the breaking of disease transmission. 1 To achieve the fast-approaching United Nations Sustainable Development Goal of global malaria elimination by 2030, 2 two processes i.e., accurate (specific and quantitative) diagnosis and appropriate (targeted drug) treatment, are crucial. Malaria is one of the most lethal and prevalent infectious diseases, which continues to cause the deaths of around half a million people each year. We discuss the challenges (and opportunities) to expedite the translation of the technology as a point-of-site tool to assist in the global eradication of malaria infection. Here, we present a comprehensive perspective on state-of-the-art hemozoin-based methodologies for detecting and studying malaria. The unique information in hemozoin formation can also shed light on the development of targeted drugs. ![]() The last decade has witnessed the development of numerous opto-/magnetic- based ultrasensitive hemozoin sensing technologies with tremendous potential of rapid and accurate malaria diagnosis and drug testing. In this respect, the identification of hemozoin during the Plasmodium growth cycle presents a unique opportunity as a biomarker for malaria infection. The development of technologies for field-deployable devices for early detection and targeted drugs/vaccines is an ongoing challenge. Immediate barriers include the detection of low-parasitemia levels in asymptomatic individuals, which act as a reservoir for future infections, and the emergence of multidrug-resistant strains in malaria-endemic, under-resourced regions. Malaria continues to be among the most lethal infectious diseases. All Vaccines Now Ship OVERNIGHT Delivery Only at a great LOW Rate! Vaccines are shipped in a cooling package.Ĭlick here for our Vaccine Shipping Schedule. See label for complete directions and precautions. Although rare, severe allergic reactions (anaphylactoid) may occur that require immediate veterinary care. Animals incubating any disease or stressed due to shipping, malnutrition, or parasitism may not achieve or maintain an adequate immune response. Annual revaccination with a single dose is recommended. All dogs over 12 weeks of age should initially receive one dose of Spectra® 10 and a second dose 2 to 3 weeks later. Puppies should be revaccinated every 2 to 3 weeks until at least 16 weeks of age. ![]() The presence of maternal antibody is known to interfere with the development of active immunity. A recommended vaccination schedule should start at or about 6 weeks of age. If blood enters the syringe freely, choose another injection site. Do not inject directly into blood vessel.īefore injecting vaccine, pull back slightly on syringe plunger. Lift the loose skin behind the neck or behind front leg and insert needle. Thoroughly prepare injection site with antiseptic. Withdraw entire contents into the syringe. Prepare the vaccine by injecting the diluent into the vial containing the desiccated vaccine cake. Open syringe by twisting or tapping the cap against a hard surface to break the heat weld. The dosage is 1 mL injected subcutaneously.
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